MU Researchers Develop Radioactive Nanoparticles that Target Cancer Cells: This is an early step toward developing therapies for metastasized cancers, MU scientist says

Home > Press > MU Researchers Develop Radioactive Nanoparticles that Target Cancer Cells: This is an early step toward developing therapies for metastasized cancers, MU scientist says

Abstract:
Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive cancers.

Columbia, MO | Posted on May 21st, 2013

"Depending on the type of cancer, primary tumors usually are not the cause of death for cancer patients," Lewis said. "If a cancer metastasizes, or spreads creating hard-to-find tumors, it often becomes fatal. Having a way to identify and shrink these secondary tumors is of utmost importance when fighting to save people with these diseases."

In an effort to find a way to locate and kill secondary tumors, Lewis, in collaboration with J. David Robertson, director of research at the MU Research Reactor and professor of chemistry in the College of Arts and Science, have successfully created nanoparticles made of a radioactive form of the element lutetium. The MU scientists then covered the lutetium nanoparticles with gold shells and attached targeting agents.

In previous research, Lewis has already proven the effectiveness of similar targeting agents in mice and dogs suffering from tumors. In that research, the targeting agents were attached to single radioactive atoms that were introduced into the bodies of animals with cancer. The targeting agents were able to seek out the tumors existing within the animals, which were then revealed through radio-imaging of those animals.

In their current research, the MU scientists have shown the targeting agents can deliver the new radioactive lutetium nanoparticles to lymphoma tumor cells without attaching to and damaging healthy cells in the process. Robertson says this is an important step toward developing therapies for lymphoma and other advanced-stage cancers.

"The ability to deliver multiple radioactive atoms to individual cancer cells should greatly increase our ability to selectively kill these cells," Robertson said. "We are very optimistic about the synergy of combining the targeting strategy developed in Dr. Lewis's lab with our work on new radioactive nanoparticles."

Lewis has been invited to present his research at the City of Hope National Medical Center this June in Duarte, Calif.

This study is an example of the collaborative research taking place in the One Health, One Medicine area of Mizzou Advantage. The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, the researchers will request permission from the federal government to begin human drug development. After this status has been granted, Lewis and Robertson may conduct human clinical trials with the hope of developing new treatments.

Lewis also is a principal investigator in the Research Service at the Harry S. Truman Memorial Veterans' Hospital. This research was supported by awards from the National Cancer Institute and the Department of Veterans Affairs as well as resources made available by Department of Veterans Affairs through use of facilities at the Harry S. Truman Memorial Veterans' Hospital in Columbia, Mo.

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Xbox One runs three operating systems, including cut-down Windows for apps

The latest update out of the currently unfolding announcement in Redmond: the next-generation Xbox will run three operating systems simultaneously. Complementing Windows 8 and RT on PCs and tablets, there'll be a third distinct version of Microsoft's operating system that has been pared down specifically for the new console. This will be the main system OS used to run apps such as Skype and other non-game titles downloaded from the Xbox storefront. At the same time, virtualization technology similar to Microsoft's Hyper-V will be used to allocate the bulk of system resources to a second, dedicated "Xbox OS" when the user loads up a game. This game OS will remain a fixed entity throughout the life of the console, so that game developers can be confident their games will run regardless of how much the Windows side of the machine gets updated. Finally, a third OS will work as a middle-man between the two, allowing the two sides of the console to talk to each other. Read on for more.

Filed under: Gaming, Home Entertainment, Microsoft

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Source: http://www.engadget.com/2013/05/21/xbox-one-runs-three-operating-systems/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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At a time when the NFL wants to get more people from other countries interested in pro football, the best strategy could be getting more people from other countries playing pro football.

As recently explained by Alex Marvez of FOXSports.com, the NFL has seen a gradual increase in the addition of foreign players, with 10 players born outside the U.S. drafted last month.? Five of them, including fifth overall pick Ziggy Ansah, were picked in the first two rounds.

Since all played college football in the U.S., it means the NFL found these players in the traditional way.? At some point, the NFL could be at the front lines of searching for players beyond our borders.

?We may be at the tip of the iceberg with this,? Falcons G.M. Thomas Dimitroff told Marvez.? ?Some very talented athletes from other countries as they learn our game and nuances will begin to excel more than others have in the past.

?I think we?ve become a lot more open-minded to the fact we will invite players outside of our country where there was once a stigma attached about not having a true understanding of football.? We now say that while they may not have a true understanding yet, the potential athleticism and phenotype suggest there?s some serious upside.?

The goal becomes finding large men who can do what NFL players need to do, and then teaching them how to do it.? ?There are big, fast, strong athletes with upside to grow into NFL players,? Dimitroff said.? ?These guys may someday be coming in waves.?

Of course, getting more people in other countries interested in football will result in more NFL body types finding the game, instead of the game having to find them.? As more foreign players make their way to America, more will become aware of the path.? Also, as more NFL football is played in places other than America, more will become aware of the game.

One major step in that direction would be the recognition of football by the International Olympic Committee.? Per Marvez, a ruling on the International Federation of American Football?s pending application is expected by June.? Eventually, a seven-on-seven version of football could become the global version of the game.

Whether it?s seven or 11 or any other number, the more exposure the game with the uniquely shaped ball gets in other countries, the more potential NFL players can be found from other places.

Of course, those who balk at the NFL taking ?our? game to other countries will surely complain about players from other countries taking NFL jobs.? But the obsession with winning will take coaches and General Managers anywhere for potential players, proving once again that a system based exclusively on merit is the best way to ensure diversity and inclusion.

Source: http://profootballtalk.nbcsports.com/2013/05/19/manuel-says-buffalos-offense-is-easier-that-florida-states/related/

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CSN: Phils touch Reds' Chapman for 2 HRs

BOX SCORE

Cliff Lee was never so disappointed to see a teammate hit a game-tying homer in the ninth inning than he was when Erik Kratz belted one deep into the left-field seats on Sunday afternoon at Citizens Bank Park.

That?s because Lee had just been picked off first base by Cincinnati?s flame-thrower closer Aroldis Chapman just two pitches before Kratz went deep.

?It was brutal,? said Lee, who was in the game as a pinch runner for Delmon Young. ?I felt horrible. [Kratz] made up for my mistake, which was unacceptable and, basically, brutal.?

Lee?s boneheaded move will be nothing more than a fun little footnote to the Phillies? dramatic 3-2 victory over the Reds. After Kratz tied the game with the home run, Freddy Galvis hit a walk-off shot just three-pitches later (see Instant Replay).

?I thought it was going to hook foul. I hit it good, but I didn?t think it was going to the wall,? Galvis said of his first walk-off. ?[It was] awesome. First time in my life and I?ll never forget it.?

It was the most improbable and dramatic victory of the season for the Phillies, and it almost didn?t happen. If Kratz had done anything other than hit a homer to tie the game in the ninth, manager Charlie Manuel would have used John Mayberry as a pinch hitter for Galvis.

Manuel said he would have gone with Mayberry because he felt the outfielder had a better chance of hitting a homer compared to Galvis. This is despite the fact that Mayberry has just two homers in 112 plate appearances this season and Galvis has three homers in 62 plate appearances.

But as the skipper says, baseball is a funny game.

?I was thinking about Mayberry?s power and that he hit a ball really hard against Chapman before,? Manuel said.

?That?s baseball and that?s the way it goes. You never know. I was thinking about sending Mayberry up there because he?s more apt to hit one out. We were down to the end there.?

Instead, Lee got picked off, setting off a whole chain of events where Kratz homered and Galvis remained in the game to hit the walk-off piece.

?It felt great. It was the best feeling I?ve had in a while when [Galvis] hit that homer to redeem my mistake,? Lee said. ?It was huge. I feel like I should be able to play fundamental baseball and that?s basically the opposite of that. That just can?t happen no matter who is running right there. You know the situation and you know the scenario and it can?t happen. It?s not going to happen again by me, I can tell you that.?

The fact that the Phillies had a chance to tie the game ? let alone win it ? is a different story all together. After being shut out for the sixth time this season in Saturday?s 10-0 loss to the Reds, the Phillies? offense wasn?t exactly in a hurry to wake up on Sunday.

Facing starter Homer Bailey, the Phillies did not cross a run in the first seven innings, pushing their scoreless innings streak to 16. In doing so, the Phillies did a nice job wasting the few opportunities they had. During three of the first four innings, they had a runner on base with one out or fewer, and they got the leadoff man on in the fourth, sixth and ninth innings.

The Phillies left runners in scoring position in the first, second, fourth and sixth and finally plated a run with two outs in the eighth when Ben Revere singled and Michael Young walked against reliever Jonathan Broxton. That set up an RBI single for Chase Utley against reliever Sean Marshall to get the Phillies to within a run.

?I thought we hit the ball hard all day. It just got caught and everything,? Manuel said. ?We stayed with them and something good happened for us at the end. That?s the way you have to do it if you?re not scoring a lot of runs.?

It helped that rookie Jonathan Pettibone turned in another solid performance, allowing just one earned run on seven hits and three walks in a career-high seven innings. In doing so, Pettibone became the first Phillies rookie to allow three earned runs or fewer in his first six career starts since Ben Rivera did it in 1992.

It also helped that the Phillies got a solid performance from relievers Justin De Fratus and Antonio Bastardo in the eighth and ninth innings, too. By keeping the game close, the Phillies had a chance.

?Huge,? said Kratz, who came into the game during the third inning when Carlos Ruiz strained his hamstring (see story). ?It wouldn?t have mattered if we got through it with seven guys in the bullpen or one guy. The job when they come in there is to keep it right there. You have to play it like a zero-to-zero game. You can?t let them get it to three because Chapman with a two-run lead is tougher than Chapman with a one-run lead. Each run is huge.?

Even the Phillies? first run of the game with two outs in the eighth was huge. Revere legged out an infield hit on an 0-2 pitch to set up a walk for Michael Young on a seven-pitch at-bat.

Where would the Phillies have been without that one run?

Better yet, where would the Phillies have been if Lee hadn?t been picked off, or if Mayberry would have hit instead of Galvis?

?It wasn?t a big deal,? Kratz said. ?If I would have hit a double in the gap, maybe it?s a little different. I?m glad Cliff [got picked off] and we won.?

Next, the Phillies hit the road for eight games starting in Miami on Monday night.

Cole Hamels (1-6, 4.61) looks to bounce back from a shaky outing against Cleveland against right-hander Alex Sanabia (2-6, 5.00) in the opener.

Source: http://www.csnphilly.com/baseball-philadelphia-phillies/kratz-galvis-make-lees-mistake-phillies-walk-win

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Local early-childhood education center honored : St Augustine ...

Recently the Child Development Education Alliance, Inc. honored Little Blessings Learning Center, located at 110 Masters Drive in St Augustine, during their first ?Gifts of Service? Awards Dinner, according to an announcement received by Historic City News today.

The honors were given in the ?Demonstrating Excellence in Serving Families? category. Little Blessing was a finalist in the category that honored church ministries in Northeast Florida who serve young children and their families.

?Little Blessing Learning Center is committed to the youth in our community; offering many free resources and activities for youth to participate in and enjoy,? Jo Davis-Baughn told local reporters. ?Being His servants, we are on a mission to show the love of Christ to each child and family that we are privileged to serve.?

The honorable Jennifer Carroll was the emcee for the evening and presented the awards. David Lawrence, Chairman of the Florida Children?s Movement, was the guest speaker.

Davis-Baughn, Chris Sikes, Olga Grove, Michelle Mauro, Jennifer Carroll, Erin Gibson, Stephen Gibson, Erica Murray, Laura Ames, April Masters, the teachers and Board of Directors of Little Blessing Learning Center, were in attendance for this recognition; as were a number of regional and state educators

Florida Commissioner of Education, Dr. Tony Bennett, provided the final thoughts on the programs honored at the celebration and their continued commitment to early childhood education.

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Source: http://historiccity.com/2013/staugustine/news/florida/local-early-childhood-education-center-honored-36742

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Friars pound Nationals, force series split

By BERNIE WILSON

AP Sports Writer

Associated Press Sports

updated 7:26 p.m. ET May 19, 2013

SAN DIEGO (AP) - After losing to Stephen Strasburg on Thursday night and then blowing an extra-inning game Friday night, the San Diego Padres righted themselves rather nicely against the defending NL East champion Washington Nationals.

Andrew Cashner pitched 6 2-3 strong innings and Kyle Blanks and Will Venable homered off Dan Haren to lead the Padres to a 13-4 victory Sunday and a split of their four-game series.

"It's huge. They have probably one of the best rotations in baseball, let alone lineups," Cashner said. `'That's a really, really good team over there. After we lost the first two we definitely played better the last two games."

After Eric Stults outpitched Jordan Zimmermann on Saturday night, the Padres got to Haren early on Sunday. The Padres tied their season high in runs and their 15 hits against four Nationals pitchers were two short of their season high.

"It was good to bounce back in beating Zimmermann, who is arguably the best pitcher in the National League right now. That was a big win last night," San Diego manager Bud Black said.

"Then to come back today against Haren, who's a great competitor. We got to him early and got him there in the middle part of the game with a couple big swings. Good for our guys. It was a good win."

San Diego's Yonder Alonso homered off Drew Storen leading off the eighth to finish 3 for 4 with two RBIs and three runs scored. It was his sixth homer.

Everth Cabrera and rookie Jedd Gyorko each had two hits, two RBIs and two runs scored. Cabrera had three stolen bases to give him a major league-leading 18.

"We're swinging really good right now and we're seeing the ball so good right now," Cabrera said. "It feels great. I'm happy."

Cashner (3-2) allowed three runs and seven hits, struck out six and walked one.

He retired the first seven Nationals batters and the Padres jumped on Haren for three runs in the first.

"Cash carried that momentum all the way through the game," Black said. "I thought he did a nice job with the fastball-change combination. He wobbled very little. I thought he was in control of the game and pitched very well."

The Nationals have lost six of nine.

Haren (4-5) got off to a rough start by allowing three runs in the first inning and was gone after the fourth-run fifth. Haren allowed nine hits while striking out five and walking two.

With the Padres leading 3-2, Venable opened the fifth with a shot deep into the stands in right field, his sixth. Haren retired the next two batters before Alonso doubled to left-center and scored on Gyorko's single to left.

Blanks then lined Haren's next pitch an estimated 383 feet off the side of the Western Metal Supply Co. brick warehouse in the left-field corner for a 7-2 lead. It was his third.

"Way too many mistakes," Haren said. "I didn't feel good out there. I didn't have much. I made a bunch of mistakes in the first inning. I kept it close for a while but you can't keep leaving balls out over the plate to a professional lineup. I kept fighting myself. I was working behind in the count too much, which is a recipe for disaster."

The Padres scored three runs against Haren in the first on three hits and a walk. Carlos Quentin and Gyorko had RBI doubles and Alonso a sacrifice fly.

The Nationals pulled to 3-2 in the fourth on Ryan Zimmerman's two-run homer that went an estimated 414 feet into the second deck in left, his third. Steve Lombardozzi was aboard on a leadoff infield single after his hard smash went off Cashner's glove. Cashner was knocked backward by the impact. He stayed in the game.

The Padres scored five runs on four hits, two walks and a sacrifice fly off Ryan Mattheus in the seventh. Cabrera had a two-run single.

"Very disappointing," Washington manager Davey Johnson said. "I hate to even talk about that one today. We didn't pitch very well. We got back in the ballgame but Haren obviously didn't have his stuff. The bullpen didn't do it. Tough day."

NOTES: The Padres had a season-high five stolen bases. ... Washington's Adam LaRoche hit an RBI single in the seventh to extend his career-best hitting streak to 16 games. ... Nationals OF Bryce Harper sat out a second straight game with a bruised left knee from his collision with the right-field wall at Dodger Stadium last Monday night. .... Haren's poor start ended a string of nine consecutive games in which Washington starters allowed two or fewer earned runs. ... The Nationals open a three-game series at San Francisco on Monday night. LHP Zach Duke (0-0, 8.40) is scheduled to start against RHP Ryan Vogelsong (1-4, 8.06). Duke is slated to make his first start since July 10, 2011, at St. Louis. ... The Padres continue their homestand with a three-game series against St. Louis that starts Monday night. The Cardinals are scheduled to start RHP Shelby Miller (5-2, 1.40) vs. RHP Jason Marquis (5-2, 3.49).

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Chooch's hammy a worry for Phils

HBT: Carlos Ruiz was lifted from Sunday afternoon?s game against the Reds after straining his right hamstring while running the bases in the bottom of the second inning.

Source: http://nbcsports.msnbc.com/id/51936146/ns/sports-baseball/

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Iran's Guard warns against post-election turmoil

TEHRAN, Iran (AP) ? A senior commander in Iran's Revolutionary Guard has warned that his forces will be on watch for possible unrest after next month's presidential election, calling the outcome "unpredictable" and sending the strongest message yet against any attempts to revive street protests, media reported Sunday.

The comments by Col. Rasool Sanaeirad point to a wide-ranging effort by Iranian authorities to intimidate opposition groups that could use the June 14 voting for possible political demonstrations.

Pro-reform groups have been under relentless pressure and crackdowns since major protests following the disputed re-election of President Mahmoud Ahmadinejad in 2009. Ahmadinejad is not running in this election because Iran's constitution bars him from seeking a third term.

But the entry of former President Akbar Hashemi Rafsanjani into the race has re-energized reformists and brought backlash from hard-liners. The Guardian Council, a group controlled by the ruling clerics, vets all candidates and a final ballot list is expected on Tuesday.

Sanaeirad was quoted Sunday as saying the "election is unpredictable," but did not elaborate.

He also warned that a "possible riot in Tehran could spread" to other regions, claiming chances for turmoil are heightened because Iran is for the first time holding both presidential and municipal balloting at the same time.

The remarks further suggest that more security controls could be imposed before the election, such as restrictions on the Internet, which was used as the critical tool by the opposition Green Movement in 2009.

Sanaeirad's comments were published in several papers, including the pro-reform Bahar daily.

Despite frequent denials by officials that Internet service will be reduced during the elections, many Web users have complained that services have become very slow and many websites have been blocked, including the pro-Rafsanjani Aftabnews.ir and Meyarnews.com, a site backing another hopeful contender, Ahmadinejad's close aide, Esfandiar Rahim Mashaei.

On Friday, a member of the influential parliamentary committee of national security and foreign policy, Mohammad Saleh Jokar, said the government will block "enemies" using the Internet to "instigate people as we witnessed in 2009."

The pro-reform Aftab daily mocked the snail's pace of the Internet, calling it "escargot" and suggesting authorities would be better off to fully halt the net.

Iranians use proxy servers and other methods to bypass censors and access many popular websites, including Facebook and Twitter, and news sites such as BBC and Voice of America.

Presumed candidates on the ballot include Rafsanjani and rivals supported by the ruling clerics, such as top nuclear negotiator Saeed Jalili, Tehran mayor Mohammad Bagher Qalibaf and former foreign minister Ali Akbar Velayati.

A major question is whether the Guardian Council will clear Ahmadinejad's choice, Mashaei. His chances are severely hampered by his association with the president, who has fallen out of favor with the ruling theocracy over his challenges to the authority of Supreme Leader Ayatollah Ali Khamenei.

On Friday, Council chief Ayatollah Ahmad Jannati said the body may disqualify candidates who seek full relations with the United States. Jannati mocked nominees who hope the international sanctions over Tehran's disputed nuclear program will end if the country restores relations with the U.S.

No high-profile candidate has proposed full restoration ? Tehran and Washington have had no diplomatic ties since 1979 ? but Rafsanjani has suggested that better relations are possible.

Source: http://news.yahoo.com/irans-guard-warns-against-post-election-turmoil-082436418.html

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Investigators eye fractured rail in Conn. train crash

By Richard Weizel

BRIDGEPORT, Connecticut (Reuters) - A fractured segment of track has been found on the rail line of a Metro-North passenger train from New York that derailed in Connecticut and struck another commuter train, injuring more than 70 people, investigators said on Saturday.

Authorities have ruled out foul play in Friday's collision, which occurred during the evening rush hour between the towns of Bridgeport and Fairfield, about 50 miles northeast of New York City.

Further examination is necessary to determine if track damage found at the site of the accident was a cause or effect of the train wreck, but that stretch of rail line had undergone repair work during the past month, officials said.

"We don't yet know whether the fractured train track caused the accident, or was caused by it," Earl Weener, a board member for the U.S. National Transportation Safety Board, told reporters at a news conference in Bridgeport.

"We do know that the back end of the eastbound train that derailed went over that part of the track where there is a fracture, and that there was repair work done on that stretch of track within the past 30 days," Weener said.

The segment of fractured rail was being sent for analysis.

The accident involved two trains from the Metro-North commuter line that runs between New York City and parts of Connecticut. The wreck occurred when several cars of an eastbound train headed from New York to New Haven, Connecticut, left the track and collided with a train coming in the opposite direction bound for New York's Grand Central Station.

More than 70 passengers and crew members were injured, officials said. Eight remained hospitalized on Saturday, three in critical condition, Connecticut Governor Dannel Malloy said.

The collision of the Metro-North trains forced Amtrak to shut down service indefinitely between New York and Boston.

The governor urged commuters who normally use the line to find alternative ways to get to work on Monday.

'FORTUNATE THERE WERE NO DEATHS'

NTSB officials arrived at the scene on Saturday to begin their investigation, which has focused in part on recent construction and repair work in the vicinity.

"The FBI was involved at the beginning, but has determined, as have we, that there was no foul play involved," Weener said.

"Frankly, we still don't know what caused the derailment and collision and will not have any answer to that question any time soon, certainly not while on site investigating," he said.

Malloy said the train cars that derailed were new and "designed to the latest standards" for safety and protection of passengers.

"To the best of our knowledge, it is the first time that a car like this has been involved in this kind of incident, and by all appearances, they responded well," Malloy said.

U.S. Senator Richard Blumenthal of Connecticut told the news conference he had come directly from St. Vincent's Medical Center, where some of the passengers and crew were being treated.

He said he was particularly struck by the courage of one conductor hurt in the collision, a woman he identified only as Helen, who despite serious back injuries helped "many of the people off the train."

"Considering the impact, we are very, very fortunate there were no deaths," Blumenthal said.

Metro-North is operated by the Metropolitan Transportation Authority, a New York state agency.

The New York-New Haven line is the busiest rail line in America and serves 125,000 commuters a day, said Judd Everhart of the Connecticut Department of Transportation.

(Additional reporting by Karen Brooks in Austin, Texas, and David Bailey in Minneapolis; Writing by Alex Dobuzinskis; Editing by Peter Cooney)

Source: http://news.yahoo.com/investigators-examine-fractured-rail-connecticut-train-crash-012857289.html

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Climate change may have little impact on tropical lizards: Study contradicts predictions of widespread extinction

May 17, 2013 ? A new Dartmouth College study finds human-caused climate change may have little impact on many species of tropical lizards, contradicting a host of recent studies that predict their widespread extinction in a rapidly warming planet.

The findings appear in the journal Global Change Biology.

Most predictions that tropical cold-blooded animals, especially forest lizards, will be hard hit by climate change are based on global-scale measurements of environmental temperatures, which miss much of the fine-scale variation in temperature that individual animals experience on the ground, said the article's lead author, Michael Logan, a Ph.D. student in ecology and evolutionary biology.

To address this disconnect, the Dartmouth researchers measured environmental temperatures at extremely high resolution and used those measurements to project the effects of climate change on the running abilities of four populations of lizard from the Bay Islands of Honduras. Field tests on the captured lizards, which were released unharmed, were conducted between 2008 and 2012.

Previous studies have suggested that open-habitat tropical lizard species are likely to invade forest habitat and drive forest species to extinction, but the Dartmouth research suggests that the open-habitat populations will not invade forest habitat and may actually benefit from predicted warming for many decades. Conversely, one of the forest species studied should experience reduced activity time as a result of warming, while two others are unlikely to experience a significant decline in performance.

The overall results suggest that global-scale predictions generated using low-resolution temperature data may overestimate the vulnerability of many tropical lizards to climate change.

"Whereas studies conducted to date have made uniformly bleak predictions for the survival of tropical forest lizards around the globe, our data show that four similar species, occurring in the same geographic region, differ markedly in their vulnerabilities to climate warming," the authors wrote. "Moreover, none appear to be on the brink of extinction. Considering that these populations occur over extremely small geographic ranges, it is possible that many tropical forest lizards, which range over much wider areas, may have even greater opportunity to escape warming."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/eLBrCTEX9VA/130517085821.htm

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Apps of the Week: Sky Gamblers, Ticket to Ride, Tweetbot, and more

Every week, the editors and writers at iMore carefully select some of our favorite, most useful, most extraordinary apps. This week's selections include a war game, a videography app, a classic board game, and a popular twitter client for Mac.

Sky Gamblers - Storm Raiders - Peter Cohen

World War II air combat on the Mac - dogfighting in the skies above Pearl Harbor, Midway, France and more. Fly historic planes with cross-platform multiplayer, Game Center and iCloud support. If you've played the game on your iOS device, you know what to expect. But Atypical Games has reworked Sky Gamblers - Storm Raiders to work on the Mac, which makes it an even more fun game on a bigger screen.

The game costs a paltry 99 cents to download, but content like new planes and weapons come at a price - in-app purchases for a couple of bucks here and there. Still, lots of fun to play and not a lot of coin to make it happen.

• $0.99 - Download now

Luma Camera - Rene Ritchie

While I was at BlackBerry Live -- or was it iMore live? -- one of the developers in attendance came over and showed me Luma Camera for iPhone. It's a video shooting app that offers filters both real-time and for post-processing, as well as optional HD video storage space via their website. The most interesting feature, however, is the image stabilization. Real optical image stabilization requires hardware, but Luma does a respectable job using the iPhones built in sensors and it's powerful graphics processing capabilities.

I haven't had much of a chance to play around with it yet, but it looks like fun. If you try it, let me know what you think!

• Free - Download now

Ticket to Ride Online - Richard Devine

I must confess to being an avid fan of the Geek and Sundry YouTube Show, TableTop starring Wil Wheaton. It's via that show I first became aware of the board game Ticket to Ride, and now I've found and begun playing the Mac version -- Ticket to Ride Online

I've never played the board game, but the Mac version is a beautifully colourful recreation of the original, and follows the rules to the letter. You choose a series of routes, and the objective is to lay trains on as many of those routes as possible before the game is up. The longest routes get an extra reward at the end, and incomplete routes loses points. It's really simple to pick up and play, and there's a comprehensive tutorial game to help you get to grips with the gameplay.

In-App purchases are available to extend the game boards, with new ones available for Europe, another USA board and for Switzerland. And, the online play supports competing against other Mac, PC, and iPad players. I've not tried out the iPad version just yet, but you'll find a link for that too below.

• $9.99 (Mac Version) - Download Now
• $6.99 (iPad Version) - Download Now

Tweetbot for Mac - Ally Kazmucha

There are a wealth of amazing Twitter clients for iOS but when it comes to Mac, there are less to choose from. While I tend to use Twitterrific on my iPhone and iPad, I've never really liked the feel of it on Mac. Tweetbot is my second favorite for iOS and when they released a Mac client a while back, it definitely didn't disappoint.

The price point is quite a bit higher than other Twitter offerings in the Mac App Store but honestly, it's the best available, hands down. If you want the iOS Tweetbot experience on your Mac, there really is no other option.

• $19.99 - Download Now

Your choice?

Now that we've chosen our favorites for the week, we want to hear yours! Did you pick up a killer app, accessory, or game this week? Let us know in the comments below!

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/EE_-phpWjDQ/story01.htm

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